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KMID : 0043320090320091185
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Archives of Pharmacal Research
2009 Volume.32 No. 9 p.1185 ~ p.1189
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Amino and Nitro Derivatives of 5,7-Dimethoxyflavone from Kaempferia parviflora and Cytotoxicity against KB Cell Line
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Chavi Yenjai
Suchana Wanich
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Abstract
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Structural modification of 5,7-dimethoxyflavone isolated from Kaempferia parviflora furnished two nitro and seven amino derivatives. Among these, six new (3, 5-6, 8-10) and three known (2, 4, 7) flavonoid derivatives were synthesized. All compounds were evaluated for cytotoxicity against KB cell line using colorimetric method. Compounds 6 and 8 exhibited strong cytotoxicity with IC50 values of 6.80 and 5.84 μg/mL, respectively.
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KEYWORD
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Kaempferia parviflora, Aminoflavonoids, Nitroflavonoids, Cytotoxicity, KB cells
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